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The number of mice with lymphoma in animals treated with busulphan (BU) at 8.25, 9.0 and 9.75 mg/kg on 10 occasions over 21 days and autopsied at 127 days after the final dose†
| BU group (mg/kg) | Number of mice sampled | Number of mice with lymphoma (%) |
|---|---|---|
| Control | 15 | 0 (0) |
| 8.25 | 14 | 4 (28.6)* |
| 9.0 | 16 | 1 (6.3) |
| 9.75 | 11 | 0 (0) |
P < 0.05 in comparison with controls; single-tailed Fisher's exact test.
No mice showed evidence of lymphoma before day 127.
