Table 2.

Molecules involved in the interactions between melanoma and macrophages

Molecules	Source	Action	References
Monocyte chemotactic protein	Melanoma cells	Increase macrophage recruitment	Kalish & Brody (1983)
Monocyte chemotactic protein (MCP-1)	Melanoma cells	Altered macrophage recruitment	Kalish & Brody (1983); Bottazzi et al. (1992)
Melanoma inhibitory activity	Melanoma cells	Enhance tumour progression and development of metastasis	Bosserhoff & Buettner (2002)
Macrophage migration inhibitory factor	Melanocytes/melanoma cells	Inhibit NK cell-mediated cytotoxicity andrandom migration of macrophages	Repp et al. (2000)
Macrophage inflammatory protein 1-α	Macrophages	Increase T-cell and dendritic cell recruitment	van Deventer et al. (2002)
Granulocyte-macrophage colony-stimulating factor	Bone marrow	Inhibit melanoma growth	Armstrong et al. (1996)
Cyclooxygenase-2	Melanoma cells	Inhibit macrophage tumouricidal activity	Duff et al. (2003)

Several molecules are involved in the interaction between the melanoma cells and the macrophages such as monocyte chemotactic protein, melanoma inhibitory activity, macrophage migration inhibitory factor, macrophage inflammatory protein 1-α, granulocyte–macrophage colony-stimulating factor, cyclooxygenase-2, direct cellular cytotoxicity and antibody-dependent cellular cytotoxicity.