Skip to main content
. 2006 Aug;87(4):253–274. doi: 10.1111/j.1365-2613.2006.00484.x

Table 1.

Properties of members of the α-crystalline Hsp protein family

Protein Molecular weight (kDa) Tissue localization References
HspB1 (Hsp27/28) 27 Breast tumours, uterus, skin, platelets, lymphoid tumours, endometrium, cervix, myocardium, glomerular epithelial and mesangial cells, ovarian and endometrial carcinoma Assimakopoulou et al. (1997); Tanigawa et al. (1997); Bex et al. (1999); Kawanishi et al. (1999); King et al. (2000); Michils et al. (2001); Tanonaka et al. (2001); Padival et al. (2003); Zagorianakou et al. (2003); Lo Muzio et al. (2004); O'Neill et al. (2004); Ciocca and Calderwood (2005); Lee et al. (2005); McLemore et al. (2005)
HspB2 (MKBP) 22 Skeletal and myocardial muscle Suzuki et al. (1998); Yoshida et al. (1999); Sugiyama et al. (2000); Golenhofen et al. (2004); Taylor and Benjamin (2005)
HspB3 (HspL27) 17/27 (150 oligomeric) Skeletal and cardiac muscle Lam et al. (1996); Sugiyama et al. (2000); Taylor and Benjamin (2005)
HspB4 (A crystallin) 20 Lens of eye, spleen and thymus (of rat) Kato et al. (1991); Rao et al. (1995); Posner (2003)
HspB5 (B crystallin) 20 Glioma cells, astrocytes, myocardium, vascular wall cells, lens of eye, head and neck tumours, platelets, lung, kidney, brain (murine) Iwaki et al. (1993); Kato et al. (1993); Ito et al. (1997b); Kozawa et al. (2001); Shu et al. (2005); Kozawa et al. (2002); Golenhofen et al. (2004); Chin et al. (2005); Pountney et al. (2005); Taylor and Benjamin (2005)
HspB6 (Hsp20/ p20) 20 Myocardium, stomach, liver, lung, kidney, brain, skeletal muscle, platelet Kozawa et al. (2002); Golenhofen et al. (2004); Gusev et al. (2005)
HspB7 (cvHsp) 23/25 Heart and skeletal muscle Verschuure et al. (2003); Taylor and Benjamin (2005)
HspB8 (Hsp22/ H11) 22–25 Heart, Brain, liver, lung, kidney, stomach, skeletal muscle, myocardium (pig) Lenne et al. (1995); Kappe et al. (2001); Verschuure et al. (2003)
HspB9 17.5 Testis Kappe et al. (2001, 2003a); De Wit et al. (2004)
HspB10(ODF1) 27/85 Testis Fontaine et al. (2003); Kappe et al. (2003a)

HspB11-B15 have been reported in non-mammalian species (Franck et al. 2004).