Table 5.
Inflammatory cells count in dystrophic muscles pre- and at the end of 6-month prednisone therapy
DMD Range (Mean ± SD) | BMD Range (Mean ± SD) | LGMD Range (Mean ± SD) | ||||
---|---|---|---|---|---|---|
Inflammatory cells | Pre-treatment | Post-treatment | Pre-treatment | Post-treatment | Pre-treatment | Post-treatment |
Total MICs (H&E) | 23.2 ± 10.1 | 18.0 ± 6.0** | 18.3 ± 5.5 | 18.3 ± 7.6 | 20.0 ± 7.5 | 20.7 ± 7.5 |
Lymphocytes (CD3 and CD20) | 3.6 ± 1.7 | 2.7 ± 1.1 | 3.3 ± 2.1 | 3.7 ± 1.2 | 2.5 ± 2.1 | 4.0 ± 1.4 |
Hitiocytes (CD68) | 12.4 ± 0.9 | 9.0 ± 3.4 | 12.3 ± 1.59.7 ± 4.2 | 13.0 ± 6.2 | 11.7 ± 4.5 | |
Dendritic cells (CD35) | 3.4 ± 0.5 | 1.8 ± 0.8** | 2.2 ± 0.7 | 1.8 ± 0.6* | 2.5 ± 0.7 | 1.5 ± 0.7 |
BMD, Becker muscular dystrophies; DMD, Duchenne muscular dystrophies; H&E, haematoxylin and eosin; LGMD, limb girdle muscular dystrophies, MIC, mononuclear inflammatory cell.
P < 0.05
P < 0.01
P < 0.001.