Table 1.
A list of surface markers used in order to characterize progenitor cells
| Marker | Also known as | Function/expression |
|---|---|---|
| C1rRp | complement protein receptor | involved in classical complement pathway |
| CD7 | gp40 | expressed on pluripotent haematopoietic cells, T-cells and thymocytes |
| CD13 | gp150, aminopeptidase-N | expressed on pluripotent granulocytes and monocytes, bile ducts and bone marrow stroma |
| CD14 | lipopolysaccharide receptor (LPS-R) | expressed on monocytes and macrophages |
| CD29 | GP11a, VLA-β, β1 integrin subunit | expressed on hepatoblasts and maintained in maturation of both hepatocyte and biliary epithelial cells |
| CD34 | GP105-120, ligand for CD62 (L-selectin) | expressed on pluripotent haematopoietic cells, capillary endothelium and embryonic liver |
| CD38 | T-10, ADP-ribosylcyclase | augments B-cell proliferation and expressed on lymphoid progenitors |
| CD44 | H-CAM, Pgp-1, Hermes ag, ECMR II, HUTCH-1, gp85 | expressed on leucocytes and erythrocytes |
| CD45 | leucocyte common ag (LCA), B220, T200 | expressed on leucocytes |
| CD49α | VLA-1α, α1 integrin | expressed on hepatoblasts, maintained in hepatocyte and lost in biliary epithelial cell maturation |
| CD49β | VLA-2α, α2 integrin | expressed on mature biliary epithelial cells, associates with CD29 |
| CD49c | VLA-3α, α3 integrin | expressed on mature biliary epithelial cells |
| CD49e | VLA-4α, α4 integrin | expressed on hepatoblasts, maintained in hepatocyte and lost in biliary epithelial cell maturation |
| CD49f | VLA-6α, α6 integrin | expressed on hepatoblasts, maintained in biliary epithelial cells and lost in hepatocyte maturation |
| CD71 | T9, transferrin receptor | expressed on proliferating cells |
| CD106 | Vascular adhesion molecule-1 (VCAM-1), INCAM110 | ligand for VLA-4, expressed on endothelial cells |
| CD117 | c-kit, stem-cell factor receptor (SCFR) | expressed on haematopoietic progenitors, mast cells and liver stem cells |
| CD123 | interleukin-3 receptor (Il-3Rα) | expressed on bone marrow stem cells, granulocytes, monocytes and megakaryocytes |
| CD124 | interleukin-4 receptor (Il-4Rα) | expressed on haematopoietic precursors and mature B - and T-cells |
| CD133 | AC133, PROML1, haematopoietic stem cell ag | expressed on haematopoietic stem cells |
| c-met | hepatocyte growth factor receptor (HGFR) | receptor for HGF which is a mitogen, motogen and morphogen |
| CXCR-4 | stromal-derived factor 1 (SDF-1R) | role in attracting stem cells |
| Flk1 | vascular endothelial growth factor receptor 2 (VEGFR2), KDR | expressed on early haematopoietic progenitor cells |
| Flt1 | vascular endothelial growth factor receptor 1 (VEGF1) | expressed on early haematopoietic progenitor cells and monocytes and megakaryocyte precursors |
| lin | lineage marker | a combination of markers of haematological or lymphoid differentiation |
| MDR1, MRP1, MRP3 | ATP-binding cassette transporter proteins | ABC transporter proteins |
| OC.2, OV6, BD1, A6 ab | antibodies raised against rodent and human oval cells and biliary epithelial cells | |
| OX43 | expressed on macrophages, endothelial cells and red-cell precursors | |
| OX44 | CD53 | expressed on myeloid and peripheral lymphoid cells |
| Sca-1 | stem cell antigen-1, lymphocyte activation protein-6A (Ly-6A) | expressed on haematopoietic progenitor cells and oval cells |
| SSEA-1 | stage-specific embryonic antigen-1 | expressed on undifferentiated rodent ES cells and differentiated human ES cells |
| SSEA-3 | stage-specific embryonic antigen-3 | expressed on undifferentiated human ES cells and differentiated rodent ES cells |
| SSEA-4 | stage-specific embryonic antigen-4 | expressed on undifferentiated human ES cells and differentiated rodent ES cells |
| TER119 | erythroid precursor marker | |
| Thy-1 | CD90 | expressed on haematopoietic progenitors and liver progenitors (oval cells) |
| Tra-1-61 | keratan sulfate-associated antigen | expressed on undifferentiated ES cells |
| Tra-1-80 | keratan sulfate-associated antigen | expressed on undifferentiated ES cells |