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. 2005 Feb;86(1):57–66. doi: 10.1111/j.0959-9673.2005.00414.x

Figure 3.

Figure 3

Subtle histological changes, which preceded frank rejection. (a and b) The regular network of reticular fibres of the red pulp (arrows) is degraded (b), 4 days after SpTx (pig #14534, group 2) (PAS stain, ×600). The normal (c) and centrally disrupted (d) patterns of reticular fibres are again observed with further staining (pig #14526, group 1, 57 days after SpTx) (reticulin stain, ×600). A TUNEL index (TI) at baseline (e) on the day of SpTx (pig #14867, group 1) is increased more than two-fold (f) 15 days after SpTx, before a subsequent biopsy showed histologic evidence of rejection 28 days after SpTx (arrows mark TUNEL+ cells) (magnification: ×200). PAS, peridodic acid-Schiff; SpTx, spleen transplantation.