Figure 1.

Atherosclerotic lesions in sections of the aortic root of the heart in a control apo E-deficient mouse (a), and in an apo E-deficient mouse receiving 3 mg/kg lacidipine (b) (haematoxylin and eosin-stained; original magnification, ×40). In the control mouse (a) extensive, advanced lesions with a well-defined fibrous cap and a necrotic core with nodular deposits of calcification are present. The volume of the lesions in apo E-deficient mouse treated with lacidipine at 3 mg/kg (b) appears markedly reduced, and the lesion is less complex.