Figure 6.

HUVEC-mediated oxidation of low-density lipoprotein (LDL)-like particles, expressed as the area under the curve (AUC, in nmol/ml/h; mean ± SEM) of malonyldialdehyde (MDA) production during a 24-h incubation period. LDL-like particles were derived from the plasma of apo E-deficient mice after 8-week treatment with vehicle, or lacidipine at 3 and 10 mg/kg. A dose-related reduction in AUC values was observed at both dose levels of lacidipine. **P < 0.01 in comparison with the cell-free medium (CFM) and the vehicle control; n = 6 for vehicle control; n = 11 for lacidipine at 3 mg/kg; n = 6 for lacidipine at 10 mg/kg and n = 8 for CFM.