Figure 7.

Vitamin E content, expressed as the area under the curve (AUC, in nmol/ml/h; mean ± SEM) during a 24-h incubation period with human umbilical vein endothelial cells (HUVECs). Low-density lipoprotein (LDL)-like particles were derived from the plasma of apo E-deficient mice after 8-week treatment with vehicle or lacidipine at 3 or 10 mg/kg. Dose-related increases in the AUC values were observed at both dose levels of lacidipine in comparison with the vehicle-treated control group; **P < 0.01; n = 6 for vehicle control; n = 11 for lacidipine at 3 mg/kg and n = 6 for lacidipine at 10 mg/kg.