Table 1.

Plasma lipid profile in control (vehicle-treated) apo E-deficient mice and in mice treated with lacidipine at 3 and 10 mg/kg for 8 weeks

Dose level of lacidipine (mg/kg)	Total cholesterol* (mmol/l)	Triglyceride* (mmol/l)	VLDL† cholesterol (mmol/l)	LDL† cholesterol (mmol/l)	HDL† cholesterol (mmol/l)
Control	36.88 ± 0.28	0.87 ± 0.03	10.00 ± 0.07	1.52 ± 0.02	0.22 ± 0.02
3	35.20 ± 0.31	1.23 ± 0.07	11.30 ± 0.05	1.72 ± 0.01	0.25 ± 0.02
10	35.20 ± 0.22	1.18 ± 0.04	12.00 ± 0.03	1.43 ± 0.03	0.33 ± 0.01

^*Values are expressed as means (±SEM); n = 20 mice in each group.

^†VLDL, very low-density lipoprotein; LDL, low-density lipoprotein; HDL, high-density lipoprotein. The level of total cholesterol in the three main lipoprotein classes (VLDL, LDL and HDL) was quantified from six pooled plasma samples taken from mice in each dose-level group. Each pooled sample was the result of taking plasma from three or four mice.