Figure 2.

Histological features of livers from mice fed a normal diet and those fed a high-fat diet for 12 weeks. (a, d, g, j,m), C57BL/6 mice; (b, e, h, k,n), LDLR^–/– mice; (c, f, i, l,o), ApoE^–/– mice. (a–c), normal diet group; (d–o), high-fat diet group. In the high-fat diet group, fatty change of liver (d–f) and ballooning degeneration of hepatocytes (g–i) are seen. Haematoxylin and eosin staining. Oil red O stain confirms lipids deposition in the liver tissue (j–l). Elastica Masson–Goldner stain shows slight-to-mild fibrosis around the central vein. Black arrows: hepatocytes with ballooning degeneration. Original magnification: a–f, ×100; m–o, ×200; g–l, ×400.