Table 1.
Effect of MG132 on protein and amino acid metabolism
Muscle | Control | MG132 | |
---|---|---|---|
Proteolysis (nmol tyrosine/g wet weight/h) | SOL (n = 8) | 82 ± 4 | 39 ± 2* |
EDL (n = 8) | 75 ± 2 | 31 ± 1* | |
Protein synthesis (nmol leucine/g of protein/h) | SOL (n = 9) | 1393 ± 67 | 1095 ± 124** |
EDL (n = 10) | 731 ± 49 | 658 ± 55** | |
Leucine oxidation (nmol leucine/g wet weight/h) | SOL (n = 10) | 74.3 ± 6.8 | 67.7 ± 6.4 |
EDL (n = 10) | 68.3 ± 4.5 | 57.4 ± 6.2*** |
Mean ± SEM. Paired t-test
P < 0.001
P < 0.01
P < 0.05. EDL, extensor digitorum longus; SOL, soleus.