Table 4.

Effects of proteasome inhibitors on the rates of proteolysis in the muscles of rats made septic by means of caecal ligation and puncture (CLP)

Muscle	CLP (n = 8)	CLP + MG132 (n = 8)	CLP (n = 9)	CLP + ZL3VS (n = 9)	CLP (n = 8)	CLP + AdaAhx3L3VS (n = 8)
SOL	83 ± 13	36 ± 2*	81 ± 4	75 ± 4	68 ± 5	54 ± 3*
EDL	76 ± 8	30 ± 2*	80 ± 5	66 ± 4*	70 ± 3	47 ± 2*

Mean ± SEM in nmol tyrosine/g wet weight/h. Paired t-test

^*P < 0.05vs. septic control. We usedanova followed by Bonferroni test to see whether the means of MG132, ZL₃VS and AdaAhx₃L₃VS are equal. Because the P-value is less than 0.05, we reject that hypothesis.