Figure 4.

Comparison of the microscopic appearances of cryoinjury-induced gastric ulcers in inducible nitric oxide synthase (iNOS^–/–) and wildtype mice. The microphotographs show haematoxylin and eosin-stained specimens from wildtype mice (a, b, c, d and e) and iNOS^–/– mice (f, g, h, i and j): (a) and (f), day 1; (b) and (g), day 3; (c) and (h), day 5; (d) and (i), day 7;(e) and (j), day 14 after ulcer induction. Aggregates of mononuclear cells in the submucosa (arrow heads) were frequently seen in specimens from iNOS^–/– mice obtained 14 days after ulcer induction (j). Bar, 100 µm.