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Effect of drug exposure on spheroids. (a) Drug response of spheroids exposed to a constant paclitaxel concentration. Spheroids were completely eliminated when exposed to concentrations greater that 1.6 nM. (b) Comparison of concentration and exposure times on spheroid growth for a fixed area under the curve (AUC) of 0.09 μmol·hrs. Longer exposure and lower concentrations had a greater effect on spheroid volume.
