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(M,R)-plane: observed data and permutation quantiles. 1-ESR1 BRCA1, 2-BRCA1 PHB, 3-KRAS2 BRCA1, 4-SLC22A18 BRCA1, 5-RAD51 BRCA1, 6-RB1CC1 SLC22A18, 7-CASP8 KRAS2, 8-CASP8 SLC22A18, 9-PIK3CA BRCA1, 10-PIK3CA ESR1, 11-PIK3CA RB1CC1, 12-PIK3CA SLC22A18, 13-BRCA1 CHEK2, 14-BARD1 BRCA1, 15-BARD1 ESR1, 16-BARD1 TP53
