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The combination of two proteomic screens of mesangial cell proteins for Akt substrates identified chaperone proteins of the cytosolic Hsp70/Hsp90 folding system, ER homologs of these proteins Grp78 and Grp94, and the ER-abundant folding catalyst, PDI. These chaperones participate in cellular responses by regulating folding, transport, and degradation of proteins. Akt phosphorylation of chaperones may contribute to mesangial cell responses during glomerular injury.
