Figure 2. The Kunitz domains of pig and human TFPI are highly conserved.
Amino acid alignments of the three Kunitz domains of pig TFPIα (P, upper) and human TFPIα (H, lower) are shown. Numbers represent the position of residues in the mature protein sequences. The residues in the P1 position of the active site cleft of each Kunitz domain of human TFPI (Girard 1989) are indicated in bold and underlined.