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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Nutr. 2008 Jul;138(7):1274–1281. doi: 10.1093/jn/138.7.1274

FIGURE 4.

FIGURE 4

Dose effects of hesperetin (A) and nobiletin or genistein (B) on luciferase reporter vectors containing regulatory sequences of the human LDLR gene from -1480 to +35 relative to the transcription start site. Transfected HepG2 cells were treated with hesperetin (n = 5), nobiletin (n = 5), or genistein (n = 3) for 24 h over a range of concentrations. Luciferase values were normalized as described in the Online Supporting Material. Error bars are ± SEM. *Different from the untreated control, P ≤ 0.05 (Dunnett’s test).