Table 1.
Effects of DZP on SE, latency to seizure cessation, and mortality as a function of age.
| Age | SE | DZP dose mg/kg | n | SE Stopped | Dose trend for SE stopped (p) | Min. to SE stop | Dose trend for Min. to SE stop (p) | Mortality | Dose Trend for mortality (p) |
|---|---|---|---|---|---|---|---|---|---|
| P9 | KA | 30 | 6 | 0 (0%) | - | NA | - | 2 (33%) | 0.24 |
| 40 | 5 | 0 (0%) | NA | 4 (80%) | |||||
| Li- Pilo | 30 | 6 | 0 (0%) | - | NA | - | 6 (100%) | - | |
| 40 | 6 | 0 (0%) | NA | 6 (100%) | |||||
| P15 | KA | 20 | 8 | 5 (63%) | 0.016 * | 1.1 ± 0.1 | 0.32 | 0 (0%) | 0.000054 * |
| 45 | 5 | 4 (80%) | 1.3 ± 0.1 | 4 (80%) | |||||
| 60 | 6 | 6(100%) | 1.2 ± 0.1 | 6 (100%) | |||||
| Li-Pilo | 20 | 10 | 6 (60%) | 0.05 * | 1.0 ± 0.1 | 0.19 | 1 (10%) | 0.000068 * | |
| 45 | 5 | 5 (100%) | 1.1 ± 0.1 | 5 (100%) | |||||
| 60 | 6 | 6 (100%) | 1.1 ± 0.1 | 6 (100%) | |||||
| P21 | KA | 20 | 6 | 0 (0%) | 0.00044 * | * | 0.56 | 0 (0%) | 0.00075 * |
| 45 | 5 | 4 (80%) | 0.9 ± 0.1 | 1 (20%) | |||||
| 60 | 5 | 3 (60%) | 0.8 ± 0.1 | 5 (100%) | |||||
| Li- Pilo | 20 | 6 | 3 (50%) | 0.86 | 1.0 ± 0.1 | 0.93 | 0 (0%) | - | |
| 45 | 6 | 3 (50%) | 0.8 ± 0.1 | 0 (0%) | |||||
| 60 | 5 | 5 (100%) | 0.9 ± 0.2 | 0 (0%) |
NA – not applicable