Table 3.

Comparison of mortality between rats exposed to SE with or without treatment.

Age	Model of SE/Drug	Dose of drug	Mortality with treatment	Mortality without treatment	p
P9	KA/DZP	30	2/6=33%	0/9=0%	0.14
		40	4/5=80%		0.005 *
	Li-Pilo/DZP	30	6/6=100%	0/5=0%	0.0022 *
		40	6/6=100%		0.0022 *
	KA/PTB	40	0/10 = 0%	0/9=0%	1.0
		45	8/8=100%		0.000041 *
	Li-Pilo/PTB	40	6/6=100%	0/5=0%	0.0022 *
		45	9/9=100%		0.000050 *
P15	KA/DZP	20	0/8=0%	2/12=17%	0.49
		45	4/5=80%		0.028 *
		60	6/6=100%		0.0015 *
	Li-Pilo/DZP	20	1/10=10%	10/12=83%	0.0019 *
		45	5/5=100%		1.0
		60	6/6=100%		0.52
	KA/PTB	30	0/5=0%	2/12=17%	1.0
		40	1/6=17%		1.0
		50	3/13=23%		1.0
	Li-Pilo/PTB	30	0/4=0%	10/12=83%	0.0082 *
		40	6/6=100%		0.53
		50	11/11=100%		0.48
P21	KA/DZP	20	0/6=0%	1/7=14%	1.0
		45	1/5=20%		0.15
		60	5/5=100%		0.02 *
	Li-Pilo/DZP	20	0/6=0%	4/6=67%	0.06
		45	0/6=0%		0.06
		60	0/5=0%		0.06
	KA/PTB	30	0/6=0%	1/7=14%	1.0
		40	0/6=0%		1.0
		50	0/11=0%		0.39
	Li-Pilo/PTB	30	1/6=17%	4/6=67%	0.24
		40	3/5=60%		1.0
		50	9/11= 82%		0.58

At P9: The treatment with DZP or PTB increased mortality in 6/8 groups; only rats with KA induced SE that were treated with DZP 30mg/kg or PTB 40mg/kg had no change in mortality.

At P15: In 8/12 groups, treatment did not have any significant change on mortality rates compared to controls. The exceptions were: rats with KA induced SE that were treated with DZP 45mg/kg or 60 mg/kg had increased mortality, while rats with KA induced SE that were treated with DZP 20mg/kg and rats with Li-Pilo induced SE that were treated with PTB 30mg/kg had lower mortality.

At P21: In rats with KA induced SE, the treatment did not significantly change mortality in any group except in the rats treated with 60mg/kg of DZP. In rats with Li-Pilo induced SE that were treated with DZP, differences in mortality between treated and untreated rats were nearly significant within each individual dose and when the 3 doses were combined, a significant decrease in mortality was observed.