. Author manuscript; available in PMC: 2009 Jul 1.

Published in final edited form as: Epilepsy Behav. 2008 Mar 11;13(1):62–69. doi: 10.1016/j.yebeh.2008.02.008

Table 4.

Comparison of mortality between rats exposed to SE and treated with rats not exposed to SE not treated with either DZP or PTB.

Age	Model of SE	Drug	Dose mg/kg	Mortality of DZP or PTB with SE	Mortality DZP or PTB without SE	p
P9	KA	DZP	30	33%	0%	0.5
	KA	PTB	40	0%	10%	1.0
	Li-Pilo	DZP	30	100%	0%	0.01 *
	Li-Pilo	PTB	40	100%	10%	0.00087 *
P15	KA	DZP	20	0%	0%	-
	KA	PTB	50	23%	23%	-
	Li-Pilo	DZP	20	10%	0%	0.45
	Li-Pilo	PTB	50	100%	23%	0.0001 *
P21	KA	DZP	20	0%	0%	-
	KA	PTB	50	0%	11%	0.45
	Li-Pilo	DZP	20	0%	0%	-
	Li-Pilo	PTB	50	82%	11%	0.006 *

At P9: In the KA model the mortality following the treatment was not different from rats without SE that were treated with DZP or PTB. In the Li-Pilo model, both treated groups had a significantly higher mortality than the groups without SE. At P15 and P21: In the KA model there was no difference in mortality between the two groups. In the Li-Pilo model rats that received PTB following SE had a significantly higher mortality than the rats that were given PTB but not exposed to Li-Pilo. There was no difference in the rats receiving DZP.