Table 3.
Risk of selected maternal and infant outcomes in HCV-positive mothers relative to HCV-negative mothers stratified by drug use
| Mothers without drug use | Mothers with drug use | |||||
|---|---|---|---|---|---|---|
| Outcome | HCV-positive without drug use | Random HCV-negative without drug use | Adjusted OR† (95% CI) | HCV-positive with drug use | HCV-negative with drug use | Adjusted OR‡ (95% CI) |
| n = 382 | n = 2005 | n = 124 | n=1439 | |||
| Maternal | ||||||
| Gestational DM | 35/379 (9) | 111/2000 (6) | 1.65 (0.92, 2.99)a,b | 2/118 (2) | 50/1431 (3) | - - - - |
| Insufficient wt gain | 9/86 (10) | 38/438 (9) | 0.89 (0.29, 2.82) | - - - - | - - - - | - - - - |
| Appropriate wt gain | 5/89 (9) | 28/500 (6) | 1.13 (0.38, 3.35) | - - - - | - - - - | - - - - |
| Excess wt gain | 16/143 (11) | 27/725 (4) | 3.09 (1.29, 7.42) | - - - - | - - - - | - - - - |
| Premature ruptured membranes | 27/374 (7) | 63/1994 (3) | 1.74 (0.98, 3.25)a | 11/114 (10) | 77/1402 (5) | 1.33 (0.60, 2.95)a,e |
| Infant | ||||||
| Low birth weight (<2500 grams) | 36/382 (9) | 71/1931 (4) | 2.15 (1.19, 3.90)b | 27/119 (23) | 249/1390 (17) | 1.19 (0.74, 1.91) |
| Prematurity (<37 wks) | 48/378 (13) | 122/1999 (6) | 1.69 (1.04, 2.73) | 34/122 (28) | 338/1413 (24) | 1.03 (0.66, 1.61) |
| Small for Gestational Age | 61/378 (16) | 174/1998 (9) | 1.62 (1.07, 2.43)c | 20/118 (17) | 225/1369 (16) | 0.97 (0.57, 1.64) |
| Neonatal jaundice | 35/382 (9) | 177/2005 (9) | 1.06 (0.67, 1.69)d | 26/124 (21) | 228/1408 (16) | 1.50 (0.94, 2.41) |
| Low apgar score (< 7) | 31/382 (8) | 97/2005 (5) | 1.42 (0.85, 2.37) | 13/124 (10) | 135/1439 (9) | 1.12 (0.60, 2.08) |
| NICU admission | 49/377 (13) | 92/1988 (5) | 3.00 (1.85, 4.86)a | 44/108 (41) | 269/1363 (20) | 2.80 (1.83, 4.29) |
| Assisted ventilation (any) | 51/377 (14) | 112/1988 (6) | 2.25 (1.40, 3.63)c | 18/108 (17) | 127/1364 (9) | 1.82 (1.03, 3.22) |
Percentages may not equal 100 due to rounding. All values given as n (%) unless indicated
Multivariate logistic regression methods used to calculate OR and 95% CI.
†
All outcomes adjusted for mother’s age, mother’s race, maternal smoking, maternal alcohol use, and prenatal care
‡
All outcomes adjusted for mother’s age, mother’s race, maternal smoking, and maternal alcohol use.
Outcomes also adjusted for:
a
– insurance status,
b
– mother’s occupation,
c
– weight gain during pregnancy,
d
– marital status,
e
– genital herpes