Table 1.
Doubling Time, Ploidy, Cdc7 Expression Level, and TP53 Gene Status in the 57 Cell Lines from the NCI-60 Set.
| Panel Name | Cell Name | Doubling Time* | Ploidy† | Cdc7 Band Intensity‡ | TP53 Gene Status |
|---|---|---|---|---|---|
| Central nervous system cancer | SNB-19§ | 34.6 | 3 | ++++ | m |
| SNB-75 | 62.8 | 2 | ++ | m | |
| U251§ | 23.8 | 2 | ++ | m | |
| SF-268 | 33.1 | 2 | + | m | |
| SF-295 | 29.5 | 5 | +++ | m | |
| SF-539 | 35.4 | 4 | + | m | |
| Colon cancer | HT29 | 19.5 | 3 | ++ | m |
| HCC-2998 | 31.5 | 2 | - | m | |
| HCT-116 | 17.4 | 2 | ++++ | wt | |
| SW-620 | 20.4 | 2 | ++++ | m | |
| COLO 205 | 23.8 | 3 | + | m | |
| HCT-15 | 20.6 | 2 | ++++ | m | |
| KM12 | 23.7 | 2 | ++++ | m | |
| Non-small cell lung cancer | NCI-H23 | 33.4 | 2 | ++++ | m |
| NCI-H226 | 61 | 3 | - | wt | |
| NCI-H322M | 35.3 | 2 | - | m | |
| NCI-H460 | 17.8 | 2 | + | wt | |
| NCI-H522 | 38.2 | 2 | +++ | m | |
| A549/ATCC | 22.9 | 3 | - | wt | |
| HOP-62 | 39 | 4 | + | m | |
| HOP-92 | 79.5 | 4 | +++ | m | |
| EKVX | 43.6 | 3 | - | m | |
| Leukemia | RPMI-8226 | 33.5 | 3 | - | m |
| K-562 | 19.6 | 3 | ++++ | m | |
| CCRF-CEM | 26.7 | 2 | + | m | |
| HL-60(TB) | 28.6 | 2 | - | m | |
| MOLT-4 | 27.9 | 4 | ++ | m | |
| SR | 28.7 | 2 | - | wt | |
| Melanoma | MALME-3M | 46.2 | 4 | - | wt |
| SK-MEL-2 | 45.5 | 4 | ++ | m | |
| SK-MEL-5 | 25.2 | 4 | - | wt | |
| SK-MEL-28 | 35.1 | 4 | - | m | |
| UACC-62 | 31.3 | 3 | - | wt | |
| UACC-257 | 38.5 | 3 | ++ | wt | |
| M14¶ | 26.3 | 3 | ++ | m | |
| MDA-MB-435¶ | 25.8 | 2 | +++ | m | |
| Kidney cancer | UO-31 | 41.7 | 2 | +++ | wt |
| SN12C | 29.5 | 3 | ++++ | m | |
| A498 | 66.8 | 3 | ++ | wt | |
| CAKI-1 | 39 | 3 | - | wt | |
| ACHN | 27.5 | 2 | ++ | wt | |
| 786-0 | 22.4 | 4 | ++++ | m | |
| TK-10 | 51.3 | 4 | ++++ | m | |
| Ovary cancer | OVCAR-3 | 34.7 | 3 | ++ | m |
| OVCAR-4 | 41.4 | 3 | + | m | |
| OVCAR-5 | 48.8 | 2 | - | wt | |
| OVCAR-8¶ | 26.1 | 2 | ++++ | m | |
| IGROV1 | 31 | 4 | ++ | m | |
| SK-OV-3 | 48.7 | 4 | - | m | |
| Prostate cancer | DU-145 | 32.3 | 3 | ++++ | m |
| PC-3 | 27.1 | 4 | ++++ | m | |
| Breast cancer | T-47D | 45.5 | 2 | - | m |
| MCF7 | 25.4 | 3 | - | wt | |
| NCI/ADR-RES$ | 34 | 2 | ++ | m | |
| BT-549 | 53.9 | 3 | ++ | m | |
| HS 578T | 53.8 | 3 | + | m | |
| MDA-MB-231/ATCC | 41.9 | 2 | ++ | m |
*
Doubling time in hours (see http://dtp.nci.nih.gov/docs/misc/common_files/cell_list.html).
†
For the ploidy, 2 means diploid, numbers greater than 2 indicate an increase of the chromosome number.
‡
Cdc7 protein expression level was scored from the immunoblot analysis presented in Figure 1 as follows: “-” indicates no Cdc7 expression; “+,” low Cdc7 expression; “≥++,” Cdc7 overexpression.
§
Indicate cell lines that were shown to be derived from the same tumor.
¶
Indicate cell lines that were shown to be derived from the same tumor.
$
Indicate cell lines that were shown to be derived from the same tumor.
m, indicates mutant; wt, wild type.