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Epo accelerates tumor growth in vivo but not in vitro. (A) Mice were inoculated with LLCs on day 0 and treated with Epo or PBS from day 1 once a week. Erythropoietin significantly accelerated tumor growth (n = 8 per group, *P < .03). (B) Lewis lung carcinoma cells (5 x 103 cells) were cultured with the indicated amounts of Epo for 48 hours. Water-soluble tetrazolium assay determined the cell number. Shown is representative of three independent experiments.
