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Pulmonary ASPS metastases contain activated myofibroblasts. The myofibroblasts surrounding clusters of cancer cells express the collagen α1(I) gene (arrows) and synthesize large amounts of collagen (stained by Sirius red). These cells and the endothelial cells of the blood vessels (BV) at the periphery of the metastasis synthesize αSMA as determined by immunohistochemistry. Original magnifications: upper panel, x40; lower panel, x400.
