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Smad3 signaling in pulmonary ASPS metastasis. The myofibroblasts in the pulmonary metastasis, but not in the surrounding lung tissue, exhibited SRF (arrows), whereas Smad3 is present both in the tumor stromal cells and lung epithelial cells. Phospho-Smad3 was demonstrated mostly in the tumor and some of the stroma cells but not by the lung epithelial cells. Original magnification, x400.
