Figure 3.

Model for regulation of uterine/placental angiogenesis and blood flow by oestrogen. This model is based on numerous studies from our laboratories and those of others in which the major players have been not only quantified but also localized to specific tissues and cell types. Note that a major feature of the model involves a positive feedback loop between endothelial cells and peri-endothelial cells (vascular smooth muscle and capillary pericytes). This figure is taken from Reynolds & Redmer (2001), with permission.