Table 3.
Haematological data† from female guinea pigs dosed with CAPS daily for 16 days at 825 mg/kg and sampled at 1, 12, 28 and 63 days after the final dose
| Day of sampling | ||||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 12 | Day 28 | Day 63 | |||||
| Control | CAPS | Control | CAPS | Control | CAPS | Control | CAPS | |
| RBC | 4.89 (0.53) | 4.58 (0.56) | 4.74 (0.54) | 4.35 (0.28) | 4.75 (0.10) | 4.66 (0.26) | 5.07 (0.30) | 5.21 (0.14) |
| HCT | 0.423 (0.030) | 0.394 (0.053) | 0.410 (0.041) | 0.371 (0.022) | 0.412 (0.009) | 0.402 (0.014) | 0.435 (0.02) | 0.440 (0.012) |
| Hb | 13.0 (0.9) | 12.1 (1.6) | 13.0 (1.2) | 11.6 (0.6) | 13.1 (0.2) | 12.3 (0.4)* | 14.1 (0.7) | 14.3 (0.4) |
| MCV | 86.9 (3.1) | 86.0 (1.8) | 86.5 (1.3) | 85.4 (1.9) | 86.6 (0.9) | 86.4 (3.3) | 85.8 (0.8) | 84.9 (1.3) |
| MCH | 26.6 (1.0) | 26.3 (0.7) | 27.5 (0.6) | 26.6 (0.5) | 27.6 (0.4) | 26.5 (1.0) | 27.7 (0.2) | 27.5 (0.2) |
| MCHC | 30.6 (0.1) | 30.6 (0.4) | 31.8 (0.2) | 31.2 (0.4) | 31.8 (0.3) | 30.7 (0.9) | 32.3 (0.1) | 32.4 (0.5) |
| Retic | 131.2 (26.4) | 16.0 (10.9)*** | 124.9 (28.4) | 206.4 (41.6)* | 71.4 (18.1) | 125.6 (62.1) | 54.0 (29.9) | 51.1 (23.2) |
| LFR | 77.6 (17.3) | 10.9 (5.7)*** | 79.8 (19.6) | 121.1 (20.9)* | 43.3 (12.2) | 73.9 (34.0) | 30.8 (9.8) | 34.3 (14.8) |
| MFR | 34.7 (10.2) | 3.1 (2.9)** | 26.8 (9.1) | 45.5 (8.9)* | 16.7 (4.3) | 27.3 (15.0) | 11.7 (8.8) | 9.4 (5.1) |
| HFR | 23.8 (5.6) | 2.1 (2.4)*** | 18.3 (12.3) | 39.8 (13.5) | 11.5 (2.3) | 24.3 (13.6) | 11.6 (11.7) | 7.4 (4.4) |
| Plt | 761 (34) | 673 (176) | 695 (9) | 731 (147) | 685 (50) | 724 (79) | 672 (150) | 460 (73)* |
| WBC | 1.6 (0.3) | 1.2 (0.8) | 2.3 (0.5) | 2.2 (0.7) | 2.4 (1.1) | 1.8 (0.6) | 2.7 (1.7) | 1.4 (0.6) |
| Neut | 0.66 (0.10) | 0.56 (0.34) | 0.74 (0.17) | 0.81 (0.28) | 0.77 (0.34) | 0.65 (0.23) | 0.58 (0.35) | 0.33 (0.12) |
| Lymph | 0.73 (0.41) | 0.60 (0.37) | 1.31 (0.42) | 1.17 (0.45) | 1.42 (0.77) | 1.07 (0.80) | 1.71 (1.08) | 0.86 (0.37) |
| Mono | 0.04 (0.02) | 0.03 (0.03) | 0.02 (0.01) | 0.04 (0.03) | 0.02 (0.02) | 0.07 (0.08) | 0.03 (0.03) | 0.03 (0.04) |
| Eo | 0.08 (0.01) | 0.02 (0.03)* | 0.07 (0.03) | 0.07 (0.07) | 0.12 (0.09) | 0.11 (0.06) | 0.12 (0.09) | 0.09 (0.12) |
| Baso | 0.01 (0.01) | 0.00 (0.01) | 0.02 (0.01) | 0.01 (0.01) | 0.00 (0.01) | 0.03 (0.04) | 0.02 (0.01) | 0.01 (0.01)* |
| LUC | 0.06 (0.02) | 0.02 (0.02)* | 0.12 (0.02) | 0.09 (0.06) | 0.08 (0.06) | 0.08 (0.08) | 0.20 (0.16) | 0.04 (0.02) |
| FNCC | 22.37 (3.80) | 6.25 (2.32)*** | 18.92 (4.22) | 14.41 (4.10) | 14.79 (2.90) | 18.04 (9.31) | 16.82 (2.39) | 13.01 (3.12) |
†
Values are means, SD in parentheses.
n = 3 (controls), n = 5 (CAPS) at all time points.
All other information as Table 1.