Skip to main content
. 2001 Jun;82(3):135–147. doi: 10.1046/j.1365-2613.2001.00191.x

Figure 2.

Figure 2

Schematic representation of the domain organization of the HTLV-1 trans-activator. The nuclear localization sequence (NLS) as well as the CREB/SRF-binding domains are located at the N-terminus of the protein. A KID-like sequence which recruits p300/CBP spans residues 81–95; a DNA-binding domain that has been shown to contact the minor-groove of the G/C-rich flanking sequences of the U3 21 bp-repeat elements is found immediately adjacent to the co-activator-binding region. The homodimerization domain overlaps the M22 mutation. A trans-activation domain overlaps the M47 mutation and is responsible for the recruitment of the co-adaptor/histone acetyltransferase, P/CAF.