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Showing the influence of patch size on the determination of clonality, here in colorectal epithelium. using X-linked markers; tumours arising within patches will perforce be clonal, and only lesions arising at the margins of patches (i.e. between A and B) will be detectable as a polyclonal proliferation. The concept can of course be extrapolated to any epithelial sheet, such as the epidermis or urothelium (from Schmidt & Mead 1990, with permission).
