Figure 1.

Northern (a) and western (b) blot analyses demonstrating high levels of SβC transgene expression in the pancreas, lacrimal gland, and muscle of 3-month-old 13592 mice. For comparison, 3-month-old 11430 and C57BL/6J mice were also used. (a) The levels of the 1.06 kb SβC mRNA in the tissues from 13592 mice are much higher than those from 11430 mice; (b) The 9–14 kDa carboxyl-terminal fragments of βPP produced from the SβC transgene were detected by the 994B antibody in the tissues. The amounts of the 9–14 kDa fragments in 13592 muscle and lacrimal gland are much higher than those in 11430 mice while the levels of the 9–14 kDa fragments in 13592 and 11 430 pancreas are similar.