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. 1999 Dec;80(6):305–315. doi: 10.1046/j.1365-2613.1999.00128.x

Figure 2.

Figure 2

Representation of the CsA sensitive mitochondrial permeability transition pore (MPTP). CsA binds to the cyclophilin in the mitochondrial membrane in an ADP dependent manner. The exact composition of the MPTP is not fully known, but it is thought to involve proteins from the cytosol including voltage dependent anion channel (VDAC), the adenine nucleotide translocator (ANT), mitochondrial cyclophilin D, the antiapoptotic proteins BCL-2, proapoptotic protein Bax, and hexokinase. Evidence exists for the involvement of these proapoptotic and antiapoptotic proteins in the formation of the MPTP complex in addition to the previously described proteins such as ANT, VDAC, cyclophilin D and hexokinase.