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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2008 Apr 11;45(3):242–255. doi: 10.1016/j.freeradbiomed.2008.03.022

Figure 5.

Figure 5

MsrA and vitamin E protect against rotenone neurotoxicity via apparently different mechanisms. (A) Western blot showing that vitamin E suppresses rotenone-induced protein carbonyl formation in primary midbrain cultures with greater efficacy than MsrA. The bracket indicates bands corresponding to the most abundant carbonylated species. (B) MsrA fails to reverse GSH depletion in rotenone-treated primary cultures, whereas vitamin E partially restores GSH levels. (C) MsrA and vitamin E suppress rotenone-induced dopaminergic cell death. The data in (B) and (C) are presented as the mean +/− SEM, N = 3; *p<0.05, **p<0.01, ***p<0.001.