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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2008 Apr 11;45(3):242–255. doi: 10.1016/j.freeradbiomed.2008.03.022

Figure 6.

Figure 6

MsrA protects primary dopaminergic neurons from toxicity elicited by mutant α-synuclein. (A) Western blot showing α-synuclein and MsrA levels in primary midbrain cultures. Bands corresponding to bovine and rat MsrA (bMsrA and rMsrA) are indicated by arrows to the right of the blot. 20 μg of protein was loaded in each lane. (B) MsrA expressed from a lentiviral construct suppresses A53T-induced dopaminergic cell death, and the protective effect of MsrA exceeds that of NAC. (C) MsrA expressed from a lentiviral construct protects against A53T-induced dopaminergic cell death with greater efficacy than vitamin E. (D) Wild-type MsrA (but not the catalytically inactive mutants C72S and C218S) expressed from an adenoviral construct suppresses A53T neurotoxicity. The data in (B)-(D) are presented as the mean +/− SEM, N = 3; *p<0.05, **p<0.01, ***p<0.001.