Table 2.

Correlation Coefficients for Change in Insulin Sensitivity (S_I [mU/L/min])

	Variable correlated with SI change	All subjects n=206	Men n=113	Women HRT − n=47	Women HRT + n=46
Baseline variables
	HDL-cholesterol baseline (log) (mmol/L)	0.05	0.24*	−0.18	−0.17
	SI baseline (log) (mU/L/min)	−0.12	0.03	−0.59†	−0.13
Cardiorespiratory fitness change
	Time to exhaustion change (sec)	0.03	0.08	−0.10	−0.05
	VO2max change (ml/min)	0.09	0.15	−0.05	−0.04
	rVO2max change (ml/kg/min)	0.09	0.15	−0.06	−0.04
Regional adiposity change
	Visceral adiposity change (cm2)	−0.13	−0.10	0.04	−0.27
	Subcutaneous adiposity change (cm2)	−0.06	−0.32†	−0.07	0.18
	Minimal waist change (cm)	−0.10	−0.28*	−0.17	0.15
	Umbilical waist change (cm)	−0.10	−0.29*	−0.07	0.10
General adiposity change
	Mass change (kg)	−0.18*	−0.24*	0.03	−0.10
	Lean body mass change (kg)	−0.02	−0.08	0.03	0.03
Serum lipoprotein change
	LDL particle concentration change (nmol/L)	−0.14	−0.04	−0.08	−0.35*
	LDL particle size change (nm)	0.18*	0.13	0.17	0.25
	HDL-cholesterol change (mmol/L)	0.06	0.10	0.17	−0.008
	Triglyceride change (mmol/L)	−0.22†	−0.14	−0.17	−0.52†
Skeletal muscle parameter change
	Capillary density change (endothelial cells:fiber)	0.09	0.01	0.49†	0.05
	Capillary density change (#/mm2)	0.11	0.02	0.44*	0.09
	Fiber area change (μm2)	0.01	0.06	−0.11	0.02
	Citrate synthase activity change (μmol/min/μg)	0.01	−0.02	−0.18	0.10

Data are presented as correlation coefficients (r) for the univariate relationship between

the indicated variable and insulin sensitivity change.

^*P<0.05

^†P<0.005