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. Author manuscript; available in PMC: 2008 Aug 19.
Published in final edited form as: J Am Chem Soc. 2006 Jun 7;128(22):7126–7127. doi: 10.1021/ja061403n

Table 1.

Dissociation Constants for Transition-State Analogue Inhibitors of Purine Nucleoside Phosphorylase.13

Entry Compound HsPNP Kd (pM) BtPNP Kd (pM)
1 graphic file with name nihms60161t1.jpg 56 ± 1514 23 ± 510
2 graphic file with name nihms60161t2.jpg 42 ± 614 30 ± 610
3 graphic file with name nihms60161t3.jpg 16 ± 111 110 ± 10
4 graphic file with name nihms60161t4.jpg 7 ± 111 23 ± 3
5 graphic file with name nihms60161t5.jpg 140 ± 1015 120 ± 20
6 graphic file with name nihms60161t6.jpg 180 ± 1015 210 ± 40
7 graphic file with name nihms60161t7.jpg 840,000 ± 110,000 380,000 ± 20,000
8 graphic file with name nihms60161t8.jpg 5,500 ± 900 21,000 ± 3,000