Figure 2: Hazard ratios for low-density lipoprotein (LDL) cholesterol levels associated with cancer at any site among patients who did not use statins (A) and among all patients with type 2 diabetes mellitus (B). The LDL cholesterol level associated with the lowest cancer risk (3.28 mmol/L) was used as the reference value. All curves were adjusted for smoking status, use of fibrates and spline functions of age, duration of diabetes, waist circumference, high-density lipoprotein cholesterol level and triglyceride levels (i.e., variables with a p value < 0.10). Figure 2A, showing hazard ratios and 95% confidence intervals, was derived from data for patients who did not use statins. Figure 2B shows two hazard ratio curves: one for people not using statins (as in Figure 2A, with data points indicated by stars), and one for the whole cohort, with further adjustment for use of statins from enrolment to date of cancer, death or censoring (data points indicated by circles).