Table 2.
Average optimized model parameters using the classical nucleated polymerization, Powers & Powers, and modified nucleated polymerization models over the specified nucleus size for polypeptides in 50 mM salts for PE at pH~3.6 and 4.1 and PEA at pH~3.6.
| Model | PE in 50mM salts at pH~3.6 | PE in 50mM salts at pH~4.1 | PEA in 50mM salts at pH~3.6 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| a (L/mol/hr) | Ks (mol/L) | Kc (mol/L) | a (L/mol/hr) | Ks (mol/L) | Kc (mol/L) | a (L/mol/hr) | Ks (mol/L) | Kc (mol/L) | |
| Classic Nucleated Polymerization (n = 3 to 40) | 2.26E+04 | 5.17E-03 | - | 3.02E+03 | 1.48E-02 | - | 1.09E+05 | 1.78E-04 | - |
| Powers & Powers Model (n = 3 to 9) | 4.90E+05 | 6.08E−02 | 3.91E−05 | 2.98E+05 | 1.38E−02 | 6.63E−06 | 4.24E+06 | 4.46E−03 | 1.76E−06 |
| Powers & Powers Model (n = 3 to 40) | 6.81E+06 | 2.84E−03 | 1.23E−06 | 1.40E+07 | 1.35E−04 | 5.20E−08 | 6.56E+07 | 9.26E−05 | 2.37E−08 |
| Modified NP Model (n = 3 to 9, constant a) | 2.03E+03 | 1.91E−05 | - | 3.43E+02 | 5.93E−02 | - | 3.47E+03 | 1.49E−04 | - |
| Modified NP Model (n = 3 to 9, variable a) | 1.94E+03 | 1.38E−05 | - | 2.00E+02 | 5.44E−04 | - | 3.67E+03 | 1.86E−05 | - |