Figure 1.
Suppressive activity of epinastine hydrochloride (EP) on angiogenic factor production from mast cells in IgE-dependent mechanism. Murine peritoneal mast cells (5 × 105 cells/mL) sensitized with IgE specific for ovalbumin (OVA) were stimulated with 10 ng/mL OVA in the presence of various concentrations of EP for 4 hours. The levels of angiogenic factors in culture supernatants were analyzed by ELISA. The data were expressed as the mean pg/mL ± SE of triplicate cultures. KC: keratinocyte-derived chemokine (a); TNF: TNF-α (b); VEGF: vascular endothelial growth factor (c);*P < .05 versus control (EP at 0 ng/mL).