Figure 2.
Influence of epinastine hydrochloride (EP) on angiogenic factor release from mast cells in IgE-dependent mechanism. Murine peritoneal mast cells (5 × 105 cells/mL) sensitized with IgE specific for ovalbumin (OVA) were stimulated with 10 ng/mL OVA. After 4 hours, cells were collected, sonically disrupted, and the levels of angiogenic factors in cytosole were examined by ELISA. The data are expressed as the mean pg/mL ± SE of triplicate cultures. KC: keratinocyte-derived chemokine (a); TNF: TNF-α (b); VEGF: vascular endothelial growth factor (c);*P < .05 versus control (EP at 0 ng/mL).