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. Author manuscript; available in PMC: 2008 Aug 20.
Published in final edited form as: Biochemistry. 2007 Jan 23;46(3):883–889. doi: 10.1021/bi0616908

Figure 3.

Figure 3

Kinetic scheme illustrating a three-step process involving a hypothetical rate-determining protein conformational changes that stabilizes post-homolysis radical intermediates. The enzyme-bound species I, II and III are those indicated in Figure 1; III* represents the conformational change in the protein. The hypothesized change in rate-determining step when deuterated substrate is used is indicated by a dashed line. The secondary kinetic and equilibrium isotope effects are indicated by dotted lines. For discussion see the text.