(A) Levels of MDA+HAE were measured in sciatic nerves from age-matched control rats (C); control rats treated with TX14(A) (C+Tx, 1 mg/kg, thrice weekly), STZ-diabetic rats (D); or STZ-diabetic rats treated with TX-14 (D+Tx, 1 mg/kg, thrice weekly). The duration of diabetes and treatment was 16 weeks. (B) Levels of MDA+HAE in sciatic nerves from age-matched control rats (C); STZ-diabetic rats (D); and STZ-diabetic rats treated with NT-3 (D+NT3; 1 mg/kg, thrice weekly). Treatment with NT-3 was initiated after 2 months of untreated diabetes and was continued for one additional month. Data are presented as mean ± SEM (N = 5–9 per group) and were analyzed by one-way ANOVA, after which multiple comparisons were made with the Bonferroni test. ** = p<0.01 and *** = p<0.001 versus control.