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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Metabolism. 2008 Jul;57(7):873–881. doi: 10.1016/j.metabol.2008.01.021

Table 2.

Body weight, blood glucose and nerve sugar levels in control rats, diabetic rats and diabetic rats treated with the aldose reductase inhibitor, ICI 222155, or insulin for the last 4 weeks of an 8-week period of diabetes.

Nerve
Body weight Blood glucose glucose sorbitol fructose myo-inositol
(g) (mM) (nmol/mg nerve dry weight)
Control 273±7* All < 15 4.1±0.6* 0.6±0.4* 0.6±0.3* 12.7±1.5*
Diabetic 236±7 All > 15 42.7±3.9 3.6±0.5 20.0±1.6 9.6±0.5
Diabetic +ARI 243±8 All > 15 56.3±3.9 0.1±0.1* 3.2±0.4* 11.9±0.7*
Diabetic +insulin 283±7* All < 15 1.3±0.4* 0.3±0.3* 0.1±0.1* 11.4±1.1*

Data are presented as mean ± SEM (N = 8–16 per group) and were analyzed by one-way ANOVA, after which multiple comparisions were made with Dunnett’s post-hoc test.

*

p<0.05 vs untreated diabetic group.