Table 3.
Baseline clinical and biological characteristics according to the ACE insertion/deletion polymorphism in the SURDIAGENE population
|
ACE genotype
|
P value: II vs. ID vs. DD | |||
|---|---|---|---|---|
| ACE II | ACE ID | ACE DD | ||
| n | 118 | 448 | 351 | |
| Age (years) | 66.1 ± 10.4 | 65.2 ± 10.6 | 64.9 ± 10.4 | 0.604 |
| Sex (male/female) | 68 (58)/50 (42) | 258 (58)/190 (42) | 184 (52)/167 (48) | 0.310 |
| Known diabetes duration (years) | 15.2 ± 9.7 | 15.1 ± 10.1 | 15.4 ± 10.0 | 0.909 |
| Systolic blood pressure (mmHg) | 131 ± 16 | 135 ± 18 | 135 ± 19 | 0.103 |
| Diastolic blood pressure (mmHg) | 72 ± 10 | 73 ± 11 | 73 ± 11 | 0.709 |
| BMI (kg/m2) | 31.0 ± 6.8 | 31.0 ± 5.8 | 31.1 ± 6.0 | 0.923 |
| Baseline urinary albumin (mg/l) | 22 (8–95) | 23 (8–129) | 25 (8–135) | 0.841 |
| Smokers (yes/no)* | 10 (8)/107 (92) | 52 (12)/389 (88) | 30 (8)/317 (92) | 0.288 |
| Serum creatinine (μmol/l) | 81.5 (72–100) | 84.5 (70–104) | 84 (70–102) | 0.488 |
| A1C (%) | 7.8 ± 1.5 | 7.9 ± 1.5 | 7.9 ± 1.5 | 0.673 |
| Personal history of myocardial infarction (yes/no) | 11 (9)/107 (91) | 62 (14)/386 (86) | 60 (17)/291 (83) | 0.099 |
| Personal history of stroke (yes/no) | 4 (3)/114 (97) | 21 (5)/427 (95) | 19 (5)/332 (95) | 0.665 |
| ESRD† | 2 (2)/116 (98) | 6 (1)/442 (99) | 7 (2)/344 (98) | 0.774 |
Data are expressed as means ± SD, medians (25th–75th percentile), or n (%).
*
Missing data for 12 patients.
†
Percent calculated among nephropathic patients.