Table 2.
First line agents | Duration of action | Start dose | Titration schedule | Maximum dose |
---|---|---|---|---|
OROS Methylphenidate HCL (Concerta) |
12 h | 18 mg qama | ↑18 mg every 7 days | 108 mg/day |
Long-acting MPH (Ritalin LA) |
8–12 | 10 mg qam | ↑10 mg every 7 days | 80 mg/day |
Controlled release Methylphenidate (Biphentin) |
10–12 h | 10 mg qam | ↑10 mg every 7 days | 80 mg/day |
Mixed Amphetamine salts XR | 12 h | 5 mg qam | ↑ 5 mg every 7 days | 60 mg/day |
(Adderall XRc) | ||||
Atomoxetine (Strattera) |
24 h | 0.5 mg/kg/day | ↑ 0.8 mg/kg/day for 10 days, then 1.2 mg/kg/day | 100 mg/day |
Second line agents | ||||
Methylphenidate HCL (Ritalin) |
3–5 h | 10 mg qam and qnoonb | ↑10 mg every 7 days | 100 mg/day |
Dextroamphetamine (Dexedrine) |
4–5 h | 5 mg qam and qnoon | ↑ 5 mg every 7 days | 60 mg/day |
Dextroamphetamine Spansule |
6–8 h | 10 mg qam | ↑ 5 mg every 7 days | 60 mg/day |
(Dexedrine spansule) |
Source: (CADDRA 2006; Paykina and Greenhill 2007).
qam – every morning.
qnoon – at noon.
Adderall XR – Adderall extended release.