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. Author manuscript; available in PMC: 2008 Aug 20.
Published in final edited form as: Biochemistry. 2007 May 3;46(21):6299–6307. doi: 10.1021/bi700079w

Figure 9.

Figure 9

Model for formation of apoA-I-DMPC discs. Three molecules of lipid-free apoA-I, each a helix bundle, intercalate into the DMPC LUV generating a constricted domain, which can pop out into an 11 nm disc containing three molecules of apoA-I and ~ 500 molecules of DMPC. An additional lipid-free apoA-I can bind to this large disc generating two 8.6 nm discs, each with two molecules of apoA-I and ~250 molecules of DMPC.