Table 2.
Association of vitamin B2, B6 and B12 baseline plasma levels and risk of colorectal adenomas
| Baseline plasma vitamin B level (quartiles) | |||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | p-value¶ | |
| Vitamin B2 (riboflavin) | 2.1-8.9 nmol/L | 9.0-15.0 nmol/L | 15.1-27.5 nmol/L | 27.6-479.0 nmol/L | |
| All adenomas | |||||
| No. recurrences/total | 109/247 | 111/249 | 104/244 | 106/246 | |
| Adjusted RR (95% CI)* | 1.00 | 1.00 (0.81-1.22) | 0.89 (0.72-1.10) | 0.88 (0.71-1.10) | 0.18 |
| Adjusted RR (95% CI)¥ | 1.00 | 1.01 (0.82-1.24) | 0.93 (0.75-1.15) | 0.95 (0.75-1.20) | 0.51 |
| Advanced lesions | |||||
| No. recurrences/total | 29/247 | 22/249 | 30/244 | 18/246 | |
| Adjusted RR (95% CI) * | 1.00 | 0.76 (0.45-1.30) | 0.96 (0.58-1.59) | 0.55 (0.30-1.01) | 0.13 |
| Adjusted RR (95% CI)¥ | 1.00 | 0.76 (0.44-1.31) | 0.95 (0.57-1.59) | 0.51 (0.26-0.99) | 0.12 |
| Vitamin B6 (PLP) | 4.7-35.6 nmol/L | 35.7-53.3 nmol/L | 53.4-84.3 nmol/L | 84.7-857.0 nmol/L | |
| All adenomas | |||||
| No. recurrences/total | 116/248 | 113/245 | 111/248 | 90/245 | |
| Adjusted RR (95% CI) * | 1.00 | 0.97 (0.79-1.18) | 0.91 (0.74-1.12) | 0.75 (0.59-0.94) | 0.02 |
| Adjusted RR (95% CI)¥ | 1.00 | 1.00 (0.82-1.22) | 0.95 (0.77-1.17) | 0.78 (0.61-1.00) | 0.08 |
| Advanced lesions | |||||
| No. recurrences/total | 23/248 | 19/245 | 36/248 | 21/245 | |
| Adjusted RR (95% CI) * | 1.00 | 0.77 (0.43-1.37) | 1.44 (0.86-2.42) | 0.86 (0.46-1.60) | 0.73 |
| Adjusted RR (95% CI)¥ | 1.00 | 0.77 (0.43-1.39) | 1.48 (0.87-2.52) | 0.89 (0.46-1.73) | 0.61 |
| Vitamin B12 | 21.4-235.9 pmol/L | 236.4-300.3 pmol/L | 300.5-388.8 pmol/L | 389.2-2479 pmol/L | |
| All adenomas | |||||
| No. recurrences/total | 115/249 | 119/246 | 98/248 | 99/247 | |
| Adjusted RR (95% CI) * | 1.00 | 1.02 (0.84-1.25) | 0.85 (0.69-1.05) | 0.88 (0.71-1.11) | 0.12 |
| Adjusted RR (95% CI)¥ | 1.00 | 1.02 (0.84-1.25) | 0.86 (0.69-1.06) | 0.91 (0.73-1.15) | 0.22 |
| Advanced lesions | |||||
| No. recurrences/total | 27/249 | 28/246 | 19/248 | 25/247 | |
| Adjusted RR (95% CI) * | 1.00 | 1.01 (0.61-1.70) | 0.69 (0.39-1.24) | 0.95 (0.53-1.68) | 0.57 |
| Adjusted RR (95% CI)¥ | 1.00 | 1.02 (0.61-1.71) | 0.69 (0.38-1.24) | 0.94 (0.52-1.69) | 0.55 |
*
Adjusted for age, sex, center, duration of follow-up, aspirin treatment group, and multivitamin use
¥
Adjusted for age, sex, center, duration of follow-up, aspirin treatment group, multivitamin use, and plasma B2, B6, B12 and folate as appropriate
¶
p-value for trend.