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Guinea pig ventricular myocyte 48 h after infection with adenovirus expressing the type 2 exchange protein activated by cAMP (Epac2- camps) biosensor. A: expression pattern illustrated by cyan fluorescent protein (CFP) fluorescence. B: pseudocolor image of the CFP-to yellow fluorescent protein (YFP) (CFP/YFP) fluorescence ratio before and after exposure to a maximally stimulating concentration (1 μM) of the β-adrenergic receptor agonist isoproterenol (Iso).
