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Both TLR2 and TLR4 transduce extracellular HSP-72 signals via NF-κB. Primary hepatocytes from TLR2- and TLR4-mutant mice were cultured and treated with Bay 11-7085, SB-203580, and SP-600125 at concentrations of 20 μM for 1 h before treatment with 1,000 ng/ml HSP-72 for 8 h. Supernatant was harvested and analyzed by ELISA for MIP-2. Data represent means ± SE of 4 experiments. *P < 0.05 compared with HSP-72.
